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ISSN: 1478-1247

Profile

 

Emma Morris
Honorary Senior Lecturer and Honorary Consultant, Department of Haematology, University College London Hospital, UK

Emma Morris

I qualified from the University of Cambridge and The Royal London Hospital in July 1992.

My initial post-graduate medical training was at Guy's and The Royal London, during which I started my specialist training in Haematology. In September 1996 I went back to Cambridge where I undertook a PhD in the Department of Haematology, funded by the Wellcome Trust.

My thesis investigated the 'functional and biochemical characterisation of an intracellular serpin associated with hematopoietic differentiation'. During these three years I was fortunate to work with some outstanding scientists who watched me struggle to learn the significant differences between basic science research and clinical medicine.  

After completion of my PhD I returned to London to complete my clinical training in Haematology at University College London Hospital. During this time I gained more experience in allogeneic bone marrow transplantation under the expert guidance of Stephen Mackinnon.

Having been bitten by the science bug during PhD training I was keen to pursue a career in Academic Haematology, and by the time I had completed my clinical training was particularly interested in the immunological aspects of allografting and immunotherapy of leukemia.

I have been funded by the Leukaemia Research Fund (LRF) since July 2002 as the LRF Bennett Senior Fellow. I am working with Professor Hans Stauss in the Department of Immunology, Imperial College, London.

My small research group is exploring various aspects of antigen-specific T cell immunotherapy, targeting both tumour associated antigens and viral antigens.

My research extends from basic immunology (T cell receptor gene transfer) to Phase I/II clinical trials.  

My clinical work is at University College London Hospital where I am an Honorary Senior Lecturer and Honorary Consultant in the department of Haematology, specialising in Bone Marrow Transplantation.

Why did you go into hematology?

Three reasons: My second ever job was as a Haematology House-Officer. It made a great impression on me - particularly the people I was working with. During that job I spent many hours looking after two particular patients: a sixteen-year-old girl with AML (whom I helped with exam revision in the evenings) and a 34-year-old man with acute grade 4 GVHD. Both patients died, but their courage was extraordinary and something I have never forgotten. Haematology offers an enormous variety within a single specialty.

Who or what has most inspired you in your work?

Four people: Dr Paul Coughlin: My Australian PhD supervisor who taught me all the basic science I know and how to persevere when experiments never seem to work. Prof Stephen Mackinnon: For his focus and determination to try new approaches to allogeneic transplantation. Prof Hans Stauss:  An outstanding scientist, a great boss and friend. Prof Ted Gordon-Smith: A source of limitless wisdom and sound judgment.

Which scientific papers have made a great impression on you?

Watson JD and Crick FHC. Molecular structure of nucleic acids. April 25th 1953  - A one-page letter revealing the basis of life.   Kolb HJ, et al. Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukaemia marrow transplant patients. Blood 1990; 76: 2462-5. - The  paper first describing the use of DLI post allograft.   Van der Bruggen P, et al. A Gene Encoding an Antigen Recognised by Cytolytic T Lymphocytes on a Human Melanoma. Science 1991; 254: 1643-7. - The paper first describing a tumour associated antigen.

What is the most important lesson you've learnt in your professional life?

There is no single lesson: Think more, talk less (a lesson I am yet to learn). Always be prepared to change your mind about both people and things. Communicate well. Enthusiasm makes up for many other deficiencies - but science requires hard work and quite a bit of luck.

What do you consider to be your greatest achievement?

Producing a son who by all accounts appears to be greater than the sum of his parts (looks-wise and character-wise) - no disrespect to my husband! Finishing the London Marathon.

What are the best and worst aspects of your job?

Best: The variety and continuous new challenges. My colleagues, many of whom are close friends.   Worst: The relentless feeling of not having enough time to achieve all you want.  Deadlines. Bureaucracy. Inability in the current climate to quickly and easily translate research into clinical practice.

When or where are you happiest?

Out cycling, walking or climbing with my husband and son. Off piste. Eating and drinking in the garden on a summer's evening. In the pub with friends. Asleep. Taking on a new challenge.

What do you do to relax?

Drink, sleep, garden and watch rubbish on the TV.

What book are you reading at the moment?

I am not very good at finishing books, I tend to get bored half way through.   Henry Porter 'Empire State' - a political thriller set post 9/11 - gripping escapism. James Watson  'DNA' - as a fan of Rosalind Franklin I am keen to read his side of the story.

What's your most evocative piece of music?

Barber: Adagio Agnus Dei. Vivaldi: Magnificat & Gloria. The theme tune from The Good, Bad and the Ugly.

What's your favorite film?

Schindler's List or Secrets and Lies.

What are your hobbies?

Sailing and Wakeboarding - neither of which I have much time to do nowadays. Swimming, running and cycling - currently training for the London Triathlon. Golf - futile hope that one day I will get better. Gardening- futile hope that it'll look good one day.

What car do you drive?

50cc Honda scooter - max speed 30mph.

What are your unfulfilled ambitions?

Wanting my son to grow into a happy and confident adult with great enthusiasm for all life has to offer. Climbing Everest, walking across the Antarctic and publishing a Nature paper…..

How would you like to be remembered?

As a person not a CV.
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